Heart Rhythm 2025 Features Advances in AI that Enhance Safety of Atrial Fibrillation Treatment

SAN DIEGO, CA, APRIL 24, 2025 – Today, the Heart Rhythm Society (HRS) unveiled new research that underscores the critical role of artificial intelligence (AI) in improving procedural safety in cardiac electrophysiology (EP), demonstrating how intelligent, real-time decision support can help mitigate risks and improve clinical confidence in complex interventions. Researchers presented these findings as an oral abstract today at Heart Rhythm 2025.

Atrial fibrillation (AF) is one of the most common arrhythmias, affecting approximately 37.5 million people worldwide, and by 2050, it’s predicted that AF cases will increase by more than 60%.ⁱ Persistent AF is a prolonged episode of AF that typically lasts more than seven days and requires medical intervention to restore sinus rhythm. While ablation has become a cornerstone of AF management, ensuring patient safety during these procedures remains a top priority for electrophysiologists. By leveraging AI, physicians can utilize advanced tools to predict patient outcomes, effectively treat challenging conditions like persistent AF, and ultimately enhance patient care.

The DeePRISM model is an AI-driven approach for predicting AF termination sites during catheter ablation to enhance procedural success. The DeePRISM model provides a real-time, automated platform for intracardiac waveform analysis during ablation, leading to better long-term results while maintaining procedural safety. The model was developed using retrospective data from 110 patients with persistent AF, incorporating deep learning and PRISM (Morphological Repetitiveness by Periodicity and Similarity) analysis to analyze intracardiac electrograms. The DeePRISM model demonstrated robust performance on the prospectively independent test set, achieving acute AF termination in 40% of patients. During the 2-year follow-up, patients who underwent DeePRISM-guided ablation experienced improved outcomes, with up to 70% remaining free from any atrial arrhythmias.

“With the introduction of the DeePRISM model, we are taking a significant step forward in the treatment of persistent atrial fibrillation,” said Chih-Min Liu, MD, PhD, Taipei Veterans General Hospital. “Our study shows that AI-driven, real-time analysis not only enhances the success of the procedure but also ensures patient safety, marking a promising advance in electrophysiology.”

Session Details

“Digital Health and Innovation – Using Artificial Intelligence to Improve the Diagnosis and Treatment of Arrhythmias: Artificial Intelligence-Driven Precision Ablation in Persistent AF: Enhancing Endocardial Signal Prediction for Ablation Success” [Thursday, April 24, 2025, at 4:00 pm PT]

ⁱ Lippi G, Sanchis-Gomar F, Cervellin G. Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge. Int J Stroke. 2021; 16(2): 217-221.

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About the Heart Rhythm Society

The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients and is the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal healthcare policies and standards. Incorporated in 1979 and based in Washington, D.C., it has a membership of more than 9,000 heart rhythm professionals from 94 countries. For more information, visit www.HRSonline.org.

About Heart Rhythm 2025

The Heart Rhythm Society’s annual Heart Rhythm meeting convenes 9,500 of the world’s finest clinicians, scientists, researchers, and innovators in cardiac pacing and electrophysiology. More than 2,000 international experts in the field will serve as faculty for the 200+ educational sessions, forums, symposia, and ceremonies, while 110+ exhibitors will showcase innovative products and services. For more information, visit www.HeartRhythm.com.